General Information

  • ID:  hor002890
  • Uniprot ID:  P11975
  • Protein name:  Neuropeptide C
  • Gene name:  NA
  • Organism:  Cardisoma carnifex (Blue land crab)
  • Family:  NA
  • Source:  animal
  • Expression:  sinus gland
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Cardisoma (genus), Gecarcinidae (family), Grapsoidea (superfamily), Thoracotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  RSADGFGRME
  • Length:  10(1-10)
  • Propeptide:  RSADGFGRMESLLTSLRGSAESPAALGEASAAHPLE
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Neuropeptide H is the precursor molecule for neuropeptides C, D, E, F and I, which arise by incomplete proteolysis of neuropeptide H.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-P60041-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P60041-F1.pdbhor002890_AF2.pdbhor002890_ESM.pdb

Physical Information

Mass: 128593 Formula: C45H72N16O16S
Absent amino acids: CHIKLNPQTVWY Common amino acids: GR
pI: 6.49 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 2
Hydrophobicity: -111 Boman Index: -3975
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 10
Instability Index: 4445 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  3298549
  • Title:  Amino acid sequences of neuropeptides in the sinus gland of the land crab Cardisoma carnifex: a novel neuropeptide proteolysis site.